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Research Summary
My research focuses on evaluating cancer prevention agents and identifying surrogate tumor markers for use in targeted clinical chemoprevention. I have ongoing translational, patient-oriented projects, in which I am investigating Barrett’s Esophagus and African-American Breast Cancer.
Research Activities
Chemoprevention is the area of cancer prevention in which pharmacological or biological agents are used to inhibit, delay or reverse carcinogenesis. Using human cancer cell lines, I am studying the anticancer effects of several candidate chemoprevention agents, including NSAID derivatives and natural compounds. I am also conducting studies of surrogate tumor biomarkers in these cells and in patient specimens to validate their use as intermediate endpoints in clinical chemoprevention trials. I am currently conducting these studies in models of Barrett’s Esophagus and African-American Breast Cancer.
Positions & Appointments
| 1999-present |
Assistant Professor, Department of Internal Medicine |
Columbia University, College of Physicians & Surgeons |
New York, NY |
| 1994-1999 |
Assistant in Clinical Medicine, Department of Internal Medicine |
Columbia University, College of Physicians & Surgeons |
New York, NY |
| 1996-1999 |
Postdoctoral Clinical Fellow, Division of Medical Oncology |
Columbia University, College of Physicians & Surgeons |
New York, NY |
| 1994-1996 |
Postdoctoral Research Fellow, Division of Infectious Diseases |
Columbia University, College of Physicians & Surgeons |
New York, NY |
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Honors and Awards
2000-2001 Avon Products Foundation Breast Cancer Research and Care Program
1999-2000 Herbert Irving Comprehensive Cancer Center Seed Grant Award
1998-2000 American Association for Cancer Research (AACR) Cancer Research Foundation of America Fellowship in Prevention Research
1995-1996 Lucille P. Markey Trust Grant
1994-1995 Hatch Foundation Fellowship
1989 Myasthenia Gravis Henry R. Viets Research Fellowship
Committees and Society Memberships
American Association for Cancer Research
American Society of Clinical Oncology
Selected Publications:
1. Joe AK, Liu H, Xiao D, Soh JW, Pinto JT, Beer DG, Piazza GA, Thompson WJ, Weinstein IB. (2003 ) Exisulind and CP248 induce growth inhibition and apoptosis in human esophageal adenocarcinoma and squamous carcinoma cells. J Exp Ther Oncol
3(2):83-94
2. Antman K, Abraido-Lanza AF, Blum D, Brownfield E, Cicatelli B, Emmons DK, Fitzgibbon M, Gapstur SM, Gradishar W, Hiatt RA, Hubbell FA, Joe AK, Klassen AC, Lee NC, Linden HM, McMullin J, Mishra SI, Neuhaus C, Olopade FI, Walas K. (2002 ) Reducing disparities in breast cancer survival: a Columbia University and Avon Breast Cancer Research and Care Network Symposium. Breast Cancer Res Treat
75(3):269-80
3. Joe AK, Liu H, Suzui M, Vural ME, Xiao D, Weinstein IB. (2002 ) Resveratrol Induces Growth Inhibition, S-phase Arrest, Apoptosis, and Changes in Biomarker Expression in Several Human Cancer Cell Lines. Clin Cancer Res
8(3):893-903
4. Joe AK, Arber N, Bose S, Heitjan D, Zhang Y, Weinstein IB, Hibshoosh H. (2001 ) Cyclin D1 overexpression is more prevalent in non-Caucasian breast cancer. Anticancer Res
21(5):3535-9
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