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Research Activities
The laboratory is carrying out research on the molecular mechanisms responsible for human diseases. The approach is to use molecular, genomic and cellular approaches to investigate basic aspects of the pathogenesis of atherosclerosis. A major focus is on molecular mechanisms of cellular cholesterol efflux, mediated by the interaction of extracellular apoA-I with the lipid transporter ABCA1. We are carrying out studies on the transcriptional regulation of ABCA1 gene expression, and regulation of the degradation of ABCA1 protein. This has led to the elucidation of a class of transcription factors (LXRs) that co-ordinately regulate cellular cholesterol efflux and reverse cholesterol transport.
Positions & Appointments
| 1997-present |
Director, Specialized Center of Research (SCOR) in Molecular Medicine and Atherosclerosis |
Columbia University, College of Physicians & Surgeons |
New York, NY |
| 1996-present |
Tilden Weger Bieler Professor of Medicine |
Columbia University, College of Physicians & Surgeons |
New York, NY |
| 1989-present |
Attending Physician |
Presbyterian Hospital |
New York, NY |
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Education and Training
| 1970 |
M.B., B.S. (honors) |
University of Sydney, Sydney, Australia |
| 1971 |
Intern |
Royal Prince Alfred Hospital, Sydney, Australia |
| 1972 |
Resident |
Royal Prince Alfred Hospital, Sydney, Australia |
| 1973-1974 |
Senior Resident, Medical Service |
Boston City Hospital, Boston, MA |
| 1974-1975 |
Gastroenterology Fellow |
University Hospital, Boston, MA |
| 1975-1976 |
Chief Resident, Medical Service |
Boston City Hospital, Boston, MA |
Honors and Awards
1996 - 1998, Tenure Review Advisory Committee, Columbia; University
1993 - 1995, Committee on Appointments and Promotions, Columbia University, Chairman, 1995.
Selected Publications:
1. Wang N, Chen W, Linsel-Nitschke P, Martinez L, Agerholm-Larsen B, Silver DL, Tall AR. (2003 ) A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I. J Clin Invest.
111(1):99-107
2. Tall AR. (2002 ) Exercise to reduce cardiovascular risk - how much is enough? N Engl J Med.
347(19):1522-4
3. Tall AR, Costet P, Wang N. (2002 ) Regulation and mechanisms of macrophage cholesterol efflux. J Clin Invest.
110(7):899-904
4. Jiang, XC, Qin, S, Qiao, C, Kawano, K, Lin, M, Xiao, X, Tall, AR. (2001 ) Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Nat. Med.
7(7):847-52
5. Luo Y, Liang CP, Tall AR. (2001 ) The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor. J Biol Chem. Jul 6;:.
276(27):24767-73
6. Welch CL, Bretschger S, Latib N, Bezouevski M, Guo Y, Pleskac N, Liang C-P, Barlow C, Dansky H, Breslow JL, Tall AR. (2001 ) Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model. PNAS
98(14):7946-51
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