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Research Summary
Dr. Brenner’s laboratory is interested in studying intracellular signaling in the liver under normal and pathophysiological states. They use animal models of human diseases including transgenic mice combined with cultures of primary and immortalized cells to study in particular the role of NFkB and JNK.
Research Activities
Dr. David A. Brenner is a leader in the field of gastroenterological research. The overall theme of his research has been the translation of basic molecular biological principles to the molecular pathophysiology of liver diseases. Over his 15 years as an independent investigator, Dr. Brenner’s research has developed into three general areas: the molecular defect in protoporphyria, intracellular signaling in hepatic proliferation and apoptosis, and hepatic fibrosis.
Positions & Appointments
| 2003-present |
Samuel Bard Professor and Chair, Department of Medicine |
Columbia University, College of Physicians & Surgeons |
New York, NY |
| 2003-present |
Member: Herbert Irving Comprehensive Cancer Center: Experimental Therapeutics, Gastrointestinal Cancer |
Columbia University |
New York, NY |
| 2002-2003 |
Director, UNC Center for Digestive Diseases and Nutrition |
University of North Carolina |
Chapel Hill, NC |
| 2001-present |
Editor-in-chief |
Gastroenterology |
New York, NY |
| 2000-2003 |
Nina C. and John T. Sessions Distinguished Professor of Digestive Diseases and Nutrition |
University of North Carolina |
Chapel Hill, NC |
Education and Training
| 1975 |
B.S. |
Yale University, New Haven, CT |
| 1979 |
M.D. |
Yale University, New Haven, CT |
| 1979-1982 |
Resident, Department of Internal Medicine |
Yale-New Haven Medical Center, New Haven, CT |
| 1982-1985 |
Medical Staff Fellow Research Associate, Genetics and Biochemistry Branch |
National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD |
| 1985-1986 |
Gastroenterology Fellow |
University of California at San Diego, San Diego, CA |
Committees and Society Memberships
Center for Gastrointestinal Biology and Disease
UNC Lineberger Comprehensive Cancer Center
UNC Program in Molecular Biology and Biotechnology
UNC Curriculum in Genetics
American Society for Clinical Investigation
American Federation for Clinical Research, National Counselor (1989-92)
American Gastroenterological Association, member of the Research
Committee (1992-1995), Teaching and Education Committee (1995-1997), and Chair, Manpower and Training Committee (1997-2000 )
American Association for the Study of Liver Diseases, member of the
Research Committee (1991-95), member of the Public Policy Committee (1996-2000)
Glaxo Institute for Digestive Health Scientific Advisory Board (1994- )
Association of American Physicians
Special Interests
Regulation of Gene Transcription
Hepatic Fibrogenesis
Porphyrias
Selected Publications:
1. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennet BL, Schoonhoven R, Brenner DA. (2003) c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology
37(4):824-32
2. Thorsten G. Lehmann; Michael D. Wheeler; Matthias Froh; Robert F. Schwabe; Hartwig Bunzendahl; R. Jude Samulski; John J. Lemasters; David A. Brenner; Ronald G.Thurman. (2003) Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Transplantation
76(1):28-37
3. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA. (2003) Toll-like receptor 4 mediates inflammatory signalling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology
37(5):1043-55
4. Osawa Y, Nagaki M, Banno Y, Brenner DA, Nozawa Y, Moriwaki H, Nakashima S. (2003) Expression of the NF-kappaB Target Gene X-Ray-Inducible Immediate Early Response Factor-1 Short Enhances TNF-alpha-Induced Hepatocyte Apoptosis by Inhibiting Akt Activation. J Immunol
170(8):4053-60
5. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T, Brenner DA, Yamaoka Y. (2003) Increased expression of collegenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. J Hepatol
38(4):468-75
6. Luedde T, Rodriguez ME, Tacke F, Xiong Y, Brenner DA, Trautwein C. (2003) p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Hepatology
37(4):833-41
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