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Research Summary
Medical application of artificial enzymes. Pathogenesis of vasodilatory shock.
Research Activities
Artificial Enzymes
We are interested in the basic science and clinical application of artificial enzymes. In particular we have developed and are investigating catalysts directed against cocaine and nerve gas.
Vasodilatory Shock
We are interested in the mechanistic basis of and treatment for vasodilatory shock. We identified the role of the ATP sensitive K-channel in septic shock and in shock due to hypoxic lactic acidosis and we discovered the syndrome of vasopressin deficiency and pressor hypersensitivity in vasodilatory shock associated with sepsis, cardiopulmonary bypass and irreversible vasodilation after hemorrhage. We are now exploring the role of vasopressin in maintaining cardiovascular stability during dialysis and vasopressin in the treatment of the hepatorenal syndrome.
Drug Discovery
We are investigating small molecule treatments for heart failure, arrhythmia, Alzheimer’s disease and various cancers in collaboration with our colleagues at the Columbia University Medical Center.
Positions & Appointments
| 2008-present |
Chair, Department of Medicine |
Columbia University, College of Physicians & Surgeons |
New York, NY |
| 2001-present |
Director, Division of Nephrology |
Columbia University, College of Physicians & Surgeons |
New York, NY |
| 1998-present |
Director, Division of Clinical Pharmacology & Experimental Therapeutics |
Columbia University, College of Physicians & Surgeons |
New York, NY |
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Education and Training
| 1975 |
B.S., Chemistry |
Lafayette College, Easton, PA |
| 1979 |
Ph.D., Organic Chemistry |
Harvard University, Cambridge, MA |
| 1983 |
M.D. |
Columbia University, College of Physicians & Surgeons, New York, NY |
| 1983-1985 |
Resident in Medicine |
Harvard Medical School, Massachusetts General Hospital, Boston, MA |
Selected Publications:
1. Deng S, Bharat N, Prada P, Landry D. (2004) Substrate-assisted antibody catalysis. Org. Biomol. Chem.
2:288-90
2. Wehrens XHT, Lehnart SE, Reiken SR, Deng S-X, Vest JA, Cervantes D, Coromilas J, Landry DW, Marks AR. (2004) Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science
304:292-6
3. Malay M-B, Ashton JL, Dahl K, Savage EB, Burchell SA, Ashton RC, Sciacca RR, Oliver JA, Landry DW. (2004) Heterogeneity of the vasoconstrictor effect of vasopressin in septic shock. Crit. Care Med.
32:1327-31
4. Larsen NA, de Prada P, Deng S-X, Mittal A, Braskett M, Zhu X, Wilson IA, Landry DW. (2004) Crystallographic and biochemical analysis of cocaine degrading antibody 15A10. Biochemistry
43:8067-76
5. Lehnart SE, Wehrens XH, Laitinen PJ, Reiken SR, Deng SX, Cheng Z, Landry DW, Kontula K, Swan H, Marks AR. (2004) Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation
109:3208-14
6. Landry DW, Zucker H. (2004) Embryonic death and the creation of human embryonic stem cells. J. Clin. Invest.
114:1184-6
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