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Presbyterian Hospital
Room 8 East, 105
622 West 168th St.
New York, NY   10032

Phone: 212-305-5839

-Columbia University College of Physicians & Surgeons
-Department of Medicine
-Division of Nephrology

Insurance Plans
Blue Choice PPO
Blue Cross Prestige
Blue Cross Senior

Hospital Affiliations
New York-Presbyterian Hospital

Donald W. Landry, MD, PhD
Samuel Bard Professor of Medicine; Chair, Department of Medicine
Physician-in-Chief, NYP/Columbia

Research Summary
Medical application of artificial enzymes. Pathogenesis of vasodilatory shock.

Research Activities
Artificial Enzymes
We are interested in the basic science and clinical application of artificial enzymes. In particular we have developed and are investigating catalysts directed against cocaine and nerve gas.

Vasodilatory Shock
We are interested in the mechanistic basis of and treatment for vasodilatory shock. We identified the role of the ATP sensitive K-channel in septic shock and in shock due to hypoxic lactic acidosis and we discovered the syndrome of vasopressin deficiency and pressor hypersensitivity in vasodilatory shock associated with sepsis, cardiopulmonary bypass and irreversible vasodilation after hemorrhage. We are now exploring the role of vasopressin in maintaining cardiovascular stability during dialysis and vasopressin in the treatment of the hepatorenal syndrome.

Drug Discovery
We are investigating small molecule treatments for heart failure, arrhythmia, Alzheimer’s disease and various cancers in collaboration with our colleagues at the Columbia University Medical Center.

Positions & Appointments
2008-present Chair, Department of Medicine Columbia University, College of Physicians & Surgeons New York, NY
2001-present Director, Division of Nephrology Columbia University, College of Physicians & Surgeons New York, NY
1998-present Director, Division of Clinical Pharmacology & Experimental Therapeutics Columbia University, College of Physicians & Surgeons New York, NY

Education and Training
1975 B.S., Chemistry Lafayette College, Easton, PA
1979 Ph.D., Organic Chemistry Harvard University, Cambridge, MA
1983 M.D. Columbia University, College of Physicians & Surgeons, New York, NY
1983-1985 Resident in Medicine Harvard Medical School, Massachusetts General Hospital, Boston, MA

Selected Publications:
1. Deng S, Bharat N, Prada P, Landry D. (2004) Substrate-assisted antibody catalysis. Org. Biomol. Chem. 2:288-90

2. Wehrens XHT, Lehnart SE, Reiken SR, Deng S-X, Vest JA, Cervantes D, Coromilas J, Landry DW, Marks AR. (2004) Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science 304:292-6

3. Malay M-B, Ashton JL, Dahl K, Savage EB, Burchell SA, Ashton RC, Sciacca RR, Oliver JA, Landry DW. (2004) Heterogeneity of the vasoconstrictor effect of vasopressin in septic shock. Crit. Care Med. 32:1327-31

4. Larsen NA, de Prada P, Deng S-X, Mittal A, Braskett M, Zhu X, Wilson IA, Landry DW. (2004) Crystallographic and biochemical analysis of cocaine degrading antibody 15A10. Biochemistry 43:8067-76

5. Lehnart SE, Wehrens XH, Laitinen PJ, Reiken SR, Deng SX, Cheng Z, Landry DW, Kontula K, Swan H, Marks AR. (2004) Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation 109:3208-14

6. Landry DW, Zucker H. (2004) Embryonic death and the creation of human embryonic stem cells. J. Clin. Invest. 114:1184-6

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