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Emmanuel Zorn, PhD

Positions and Appointments

2010-present  Adjunct Assistant Professor of Surgery
Columbia University College of Physicians and Surgeons, New York, NY
2010-present  Director, Sample Repository, Columbia Center for Translational Immunology
Columbia University College of Physicians and Surgeons, New York, NY

Research Interests

Antibody mediated rejection of human kidney grafts

B cell immunity following solid organ transplantation

Natural antibodies and ischemia reperfusion injury following kidney transplantation

Education and Training

1999-2002  Research Fellowship
Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA
1994-1999  PhD,Tumor Immunology
Necker Hospital, Paris University, France
1994  MS, Immunology
Paris University, France

Professional Experience

2009-present  Assistant Professor of Surgery
Harvard Medical School, Boston, MA
2007-present  Associate Immunologist
Massachusetts General Hospital, Boston, MA
2006-present  Director, Transplant Center Sample Repository
Massachusetts General Hospital, Boston, MA
2006 - 2009  Assistant Immunologist
Massachusetts General Hospital, Boston, MA
2006 - 2007  Instructor in Surgery
Massachusetts General Hospital, Harvard Medical School, Boston, MA
2002 - 2006  Instructor in Medicine
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
1999 - 2002  Research Fellow
Dana-Farber Cancer Institute, Harvard Medical School , Boston, MA

Professional Societies and Committees

2007-present The Transplantation Society, member
2007-present American Society of Transplantation, member
2006-present American Society of Nephrology, member

Selected Publications

Porcheray F, DeVito J, Yeap BY, Xue L, Dargon I, Paine R, Girouard TC, Saidman SL, Colvin RB, Wong W and Zorn E. Chronic humoral rejection of human kidney allografts associates with broad autoantibody responses. Transplantation. In press.

Porcheray F, Wong W, Saidman SL, DeVito J, Girouard TC, Chittenden M, Shaffer J, Tolkoff-Rubin N, Bimalangshu DR, Spitzer TR, Colvin RB, Cosimi AB, Kawai T, Sachs DH, Sykes M, and Zorn E. B cell immunity in the context of T cell tolerance after combined kidney and bone marrow transplantation in humans. American J. Transplant. 2009; 9:2126-35. PMID: PMC 19624570

Zorn E, Mohseni M, Kim, H, Porcheray F, Lynch A, Bellucci R, Canning C, Alyea EP, Soiffer RJ and Ritz J. Combined CD4+ donor lymphocyte infusion and low-dose recombinant IL-2 expand FOXP3+ regulatory T cells following allogeneic hematopoietic stem cell transplantation. Biol Bone and Marrow Transplant. 2009; 15:382-8. PMID: PMC 19203731

Bellucci R, Oertelt S, Gallagher M, Li S, Zorn E, Weller E, Porcheray F, Alyea EP, Soiffer RJ, Munshi NC, Gershwin ME, Ritz J. Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis. Blood. 2007; 109: 2001-7. PMID: PMC 17068145

Zorn E, Nelson EA, Mohseni M, Porcheray F, Kim H, Litsa D, Bellucci R, Raderschall E, Canning C, Soiffer RJ, Ritz J. IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT dependent mechanism and induces the expansion of these cells in vivo. Blood. 2006;108:1571-9. PMID: PMC 16645171

Zorn E, Kim HT, Lee SJ, Floyd BH, Litsa D, Arumugarajah S, Bellucci R, Alyea EP, Antin JH, Soiffer RJ and Ritz J. Reduced frequencies of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic Graft-versus-Host-Disease. Blood. 2005; 106: 2903-2911. PMID: PMC 15972448

Bellucci R, Alyea EP, Chiaretti S, Wu CJ, Zorn E, Weller E, Wu B, Canning C, Schlossman R, Munshi NC, Anderson KC, Ritz J. Graft versus tumor response in patients with multiple myeloma is associated with antibody response to BCMA, a plasma cell membrane receptor. Blood. 2005; 105: 3945-3950. PMID: PMC 15692072

Miklos DB, Kim HT, Miller KH, Guo L, Zorn E, Lee SJ, Hochberg, EP, Wu CJ, Alyea EP, Cutler C, Ho V, Soiffer RJ, Antin JH, Ritz J. Antibody Responses to H-Y Minor Histocompatibility Antigens Correlate with Chronic Graft versus Host Disease and Disease Remission. Blood. 2004; 105: 2973-2978. PMID: PMC 15613541

Zorn E, Miklos DB, Floyd B, Mattes-Ritz A, Guo L, Soiffer RJ, Antin JH, Ritz J. Minor Histocompatibility Antigen DBY Elicits a Coordinated B and T Cell Response After Allogeneic Stem Cell Transplantation. J Exp Med. 2004; 199:1133-1142. PMID: PMC 15096539

Miklos DB, Kim HT, Zorn E, Hochberg EP, Guo L, Mattes-Ritz A, Viatte S, Soiffer RJ, Antin JH, Ritz J. Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in normal female donors. Blood 2004; 103: 353-359. PMID: PMC 14512314

Zorn E, Wang KS, Hochberg EP, Canning C, Alyea EP, Soiffer RJ, Ritz J. Infusion of CD4 positive donor lymphocytes induces the expansion of CD8 positive donor T cells with cytolytic activity directed against recipient hematopoietic cells. Clin Cancer Res 2002; 8: 2052-2060. PMID: PMC 12114403

Wang KS, Zorn E, Ritz J. Specific down-regulation of IL-12 signaling through induction of phospho-STAT4 protein degradation. Blood 2001; 97: 3860-3866. PMID: PMC 11389027

Zorn E, Orsini E, Wu CJ, Stein B, Chillemi A, Canning C, Alyea EP, Soiffer RJ, Ritz J. A CD4+ T cell clone selected from a CML patient after donor lymphocyte infusion recognizes BCR-ABL breakpoint peptides but not tumor cells. Transplantation 2001; 71: 1131-1137. PMID: PMC 11374415

Zorn E, Hercend T. A MAGE-6-encoded peptide is recognized by expanded lymphocytes infiltrating a spontaneously regressing human primary melanoma lesion. Eur J Immunol 1999; 29: 602-7. PMID: PMC 10064076

Zorn E, Hercend T. A natural cytotoxic T cell response in a spontaneously regressing human melanoma targets a neoantigen resulting from a somatic point mutation. Eur J Immunol 1999; 29: 592-601. PMID: PMC 10064075

(Visit PubMed to view this faculty member's most recent articles.)

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