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Address:
William Black Medical Res. Building
Room 905
650 W. 168th St.
New York, NY   10032

Phone: (212) 305-3725

Affiliations
-Columbia University College of Physicians & Surgeons
-Department of Medicine
-Division of Endocrinology

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Hospital Affiliations
New York-Presbyterian Hospital


Judith Korner, M.D., Ph.D.
Florence Irving Assistant Professor of Clinical Medicine

Research Summary
My research interests are focused on the hypothalamic regulation of energy homeostasis and the development of treatments for obesity. I am interested in the molecular mechanisms by which several hormones discovered over the past few years control food intake. I am studying the neuroendocrine changes that occur with weight loss in both rodent models and obese humans.

Research Activities
Animal Studies:
§ Examining the role of agouti-related protein (AGRP) in regulating food intake. AGRP is a hypothalamic peptide that increases food intake in rodents by antagonizing the action of alpha-melanocyte stimulating hormone (a-MSH), a peptide that acts to decrease food intake, at melanocortin receptors within the brain.
§ Examining the role of the dopaminergic system in energy homeostasis and insulin sensitivity.
§ Using rodent models to design effective weight loss strategies for future use in humans. One such study involves combination treatment with naloxone (an opioid antagonist) and leptin (a peptide hormone produces by adipocytes).
Human Studies:
§ Analysis of hormones involved in energy homeostasis before and after bariatric surgery (gastric bypass and banding) and implantation of a gastric pacemaker, an experimental procedure used for weight reduction.
§ Exploration of different therapies for the treatment of hypothalamic obesity.

Positions & Appointments
1999-present Assistant Attending Physician Presbyterian Hospital New York, NY
1999-present Assistant Professor of Clinical Medicine Columbia University, College of Physicians & Surgeons New York, NY
1997-1999 Post-Doctoral Clinical Fellow, Endocrinology Columbia University Medical Center New York, NY
1996-1997 Instructor in Clinical Medicine Columbia University, College of Physicians & Surgeons New York, NY
1996-1997 Chief Resident and Clinical Assistant Physician, Internal Medicine Columbia University Medical Center New York, NY


Education and Training
1979 B.A. Barnard College, Columbia University, New York, NY
1992 Ph.D., Biochemistry and Molecular Biophysics Columbia University, New York, NY
1993 M.D. Columbia University, College of Physicians & Surgeons, New York, NY

Honors and Awards
1979 Magna Cum Laude, Barnard College, Columbia University
1979 Phi Beta Kappa, Barnard College, Columbia University
1979 Dean's Prize, Barnard College, Columbia University
1990 Dean's Day Medical Student Research Award, College of Physicians & Surgeons, Columbia University
1993 Upjohn Research Award
1998 Endocrine Fellows Foundation Grant
1998 NIH Feasibility Award, New York Obesity Research Center
1999 NIH Feasibility Award, New York Obesity Research Center

Committees and Society Memberships
Endocrine Society; American Association of Clinical Endocrinologists; American
Diabetes Association; American Medical Association; North American Association for the Study of Obesity

Special Interests
Weight loss management; Neuroendocrinology

Selected Publications:
1. Korner, J., Lo, J., Freda, P.U., and Wardlaw, S.L. (2003 ) Weight loss in patients with hyperprolactinemia treated with cabergoline.
Obesity Research 11:311-312

2. Korner, J., Savontaus, E., Chua Jr., S.C., Leibel, R.L., and Wardlaw, S.L. (2001) Differential regulation of Agrp and Npy mRNA in the rat hypothalamus. J. of Neuroendocrinology 13:959-66

3. Korner, J., Wardlaw, S.L., Liu, S.-M., Conwell, I.M., Leibel, R.L., Chua Jr., S.C. (2000) Effects of leptin receptor mutation on Agrp gene expression in fed and fasted lean and obese (LA/N-faf) rats. Endocrinology 141:2465-71

4. Korner, J., Chua Jr., S.C., Williams, J.A., Leibel, R.L., Wardlaw, S.L. (1999) Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats. Neuroendocrinology 70:377-83

 
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