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Research Summary
Metabolic Bone Diseases
Primary Hyperparathyroidism
Osteoporosis
Mechanisms of Parathyroid Hormone Action
Research Activities
Dr. Bilezikian oversees a very active program of clinical investigation in a number of different metabolic bone diseases. The group of investigators who work with him includes Drs. Ethel Siris (Madeline Stabile Professor of Clinical Medicine and Director, Toni Stabile Osteoporosis Center); Elizabeth Shane (Professor, and Director, Transplantation Bone Disease Program); Shonni Silverberg (Professor), Carolyn Becker (Associate Clinical Professor and Associate Director, Toni Stabile Osteoporosis Center), Etah Kurland (Assistant Professor); and Mishaela Rubin (Instructor). Drs. Bilezikian and Silverberg head the longest and largest prospective study of primary hyperparathyroidism that has ever been conducted. With continuous NIH support, it is now in its twentieth year. With Drs. Silverberg and Rubin, promising new non-surgical approaches to primary hyperparathyroidism are being explored. These investigators have also developed research projects related to the cardiovascular, cognitive, and nutritional aspects of primary hyperparathyroidism. Drs. Bilezikian, Silverberg, and Rubin are also studying a clinical problem that is opposite to that of primary hyperparathyroidism, namely parathyroid hormone deficiency (hypoparathyroidism). Drs. Kurland and Bilezikian are studying osteoporosis in men with particular interests on clinical, histomorphometric, densitometric, genetic and therapeutic elements. Dr. Siris is the medical director of one of the largest epidemiologist surveys of skeletal ever conducted. Dr. Shane (see her separate listing) is one of the pioneers in the investigation of bone loss that occurs after organ transplantation. She is also conducting a study of osteoporosis in premenopausal women. Dr. Becker is heading a study of the patient who has sustained a fragility fracture of the hip. She is interested in the challenges of identifying such patients in an inpatient setting and developing therapeutic approaches with which fracture healing can be accelerated. With Drs. Ronald Katz and Ciao, Dr. Bilezikian conducts a laboratory-based research project focused upon the cellular and biochemical mechanisms of parathyroid hormone and bisphosphonate action.
Positions & Appointments
| 1996-present |
Associate Chair (Education), Department of Medicine |
Columbia University, College of Physicians & Surgeons |
New York, NY |
| 1990-1996 |
Director, Medical House Staff Training Program, Department of Medicine |
Columbia University, College of Physicians & Surgeons |
New York, NY |
| 1987-present |
Chief, Division of Endocrinology |
Columbia University, College of Physicians & Surgeons |
New York, NY |
| 1985-present |
Professor of Medicine and Pharmacology, Departments of Medicine and Pharmacology |
Columbia University, College of Physicians & Surgeons |
New York, NY |
| 1985-present |
Attending Physician |
Presbyterian Hospital |
New York, NY |
Education and Training
| 1965 |
B.A. - Biochemistry, Magna Cum Laude |
Harvard College, Cambridge, MA |
| 1969 |
M.D. |
Columbia University, College of Physicians & Surgeons, New York, NY |
Honors and Awards
1965 L. J. Henderson Prize, Biochemistry, Harvard College
1968 Alpha Omega Alpha (Columbia University, Physicians & Surgeons Chapter)
1976 J. Murray Steele Award, New York Heart Association
1977 Steven Triennial Prize, College of Physicians & Surgeons
1977-1982 Research Career Development Award, National Institutes of Health
1987-1989 President, Alumni Association, College of Physicians & Surgeons
1991 Silver Medal, College of Physicians & Surgeons, Alumni Association
1992 Lillian Clark Visiting Professor in Mineral Metabolism, The University of Texas, Southwestern Medical Center at Dallas
1993 Alumni Medal, Alumni Federation of Columbia University
1995-1996 President, American Society for Bone and Mineral Research
1994-1995 Doody Award: THE PARATHYROIDS (For Best Health Science Books)
1995 Society for Clinical Densitometry (First Honorary Member)
1995 Visiting Professor in Endocrinology, Department of Medicine, University of Maryland
1996 Endocrine Fellows Foundation Visiting Lectureship Award
1996 The MacPherson Visiting Professor and Physician-in-Chief Pro Team, Deaconess Hospital, Harvard Medical School, Boston, MA
1996 Visiting Professor, Hong Kong University Medical School, Hong Kong
1997 Visiting Professor and John Edson Lecturer, Long Island College Hospital
1996-1997 Doody Award: PRINCIPLES OF BONE BIOLOGY (For Best Health Science Books)
1997 Visiting Professor, Bone and Mineral Metabolism, Beth Israel Hospital, Harvard Medical School, Boston, MA
1997 Mayo Clinic Distinguished Lecturer in Medical Science, Rochester, Minnesota
1997 ASBMR Abstract Presentation Award: Outstanding Research in the Pathophysiology of Osteoporosis (shared with Drs. A. Morishima and M. Grumbach)
1997 Plenary Lecturer: 27th Annual Meeting of the Endocrine Society of India
1998 Distinguished Physician Award, Endocrine Society
1998 Neil Auerbach Memorial Lecturer, Norwalk Hospital
1998 Boy Frame Distinguished Lecturer, Henry Ford Hospital
1999 Featured Lecturer, 3rd International Congress on Osteoporosis, Xian, China
1999 Invited Speaker, 13th Annual Smithwick Symposium, Boston University
1999 Plenary Lecturer, Swiss Bone and Mineral Society, Berne Switzerland
1999 Tisdale Lecturer, University of Vermont Medical School
1999 Invited Speaker, 4th International Conference on New Actions of Parathyroid Hormone, Malta
1999 Honarary Professor of the Medical Faculty, University of Heidelberg
1999 Honorary Member, Sociedade Brasileira para o Estudo do Metabolismo Osseoe Minard
1999 Featured Speaker, First Congress of the Brazilian Society of Bone and Mineral Metabolism and Sixth International Symposium on Metabolic Bone Diseases, Recife, Brazil
2000 Speaker, NIH Consensus Development Conference on Osteoporosis
2000 Featured Speaker, IV Argentine Osteoporosis Congress and II Mercosur Congress of Metabolic Bone and Mineral Diseases, Buenos Aires
Committees and Society Memberships
1974 American Federation for Clinical Research
1977 Endocrine Society
1979 American Society for Bone and Mineral Research
1980 American Society for Pharmacology & Experimental Therapeutics
1980 The American Society for Clinical Investigation
1982 Fellow, American College of Physicians
1987 American Heart Association
1989 International Bone and Mineral Society
1990 Association of Program Directors in Internal Medicine
1993 Association of American Physicians
1994 Fellow, New York Academy of Medicine
1994 American Association of Clinical Endocrinologists
1995 International Society for Clinical Densitonmetry
1995 Fellow, American College of Endocrinology
1995 Association of Programs Directors in Endocrinology and Metabolism
1995 Association of Osteobiology
Selected Publications:
1. Black DM, Greenspan SL, Ensrud KE, Palermo L, McGowan JA, Lang TF, Garnero P, Bouxsein ML, Bilezikian JP, Rosen CJ (2003) The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Eng J Med
349:1207-15
2. Silverberg SJ, Bilezikian JP (2003) “Incipient” primary hyperparathyroidism: a “forme fruste” of an old disease. J Clin Endocrinol Metab
88:5348-52
3. Silverberg SJ, Brown I, LoGerfo P, Gao P, Cantor T, Bilezikian JP (2003) Clinical utility of an immunoradiometric assay for whole PTH (1-84) in primary hyperparathyroidism. J Clin Endocrinol Metab
88:4725-30
4. Siris ES, Bilezikian JP, Rubin MR, Black D, Bockman R, Bone HG, Hochberg MC, McClung MR, Schnitzler TJ (2003) Pins and plaster aren’t enough: A call for the evaluation and treatment of patients with osteoporotic fractures. J Clin Endocrinol Metab
88:3482-6
5. Rubin MR, Bilezikian JP (2003) New anabolic therapies in osteoporosis. Endocrinology and Metabolism Clinics of North America
32:285-308
6. Bilezikian JP, Potts JT, El-Hajj Fuleihan G, Kleerekoper M, Neer R, Peacock M, Rastad J, Silverberg SJ, Udelsman R, Wells SA (2002) Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st century. J Bone Min Res
17 Suppl 2:N2-N11
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