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Research Summary
The translation of basic scientific advances into clinically useful therapeutic devices and drugs for the treatment of cardiovascular disease.
Research Activities
Using a combination of bioengineering and pharmacological approaches, we are studying methods to modify proliferative vascular responses after various vascular manipulations, such as angioplasty, stent implantation, or arteriovenous fistulae. For example, our lab pioneered the use of intravascular radiation therapy (brachytherapy) for the prevention and treatment of restenosis following angioplasty and stenting. Members of the lab have included basic science post-doctoral fellows, clinical cardiology and vascular surgery fellows, and bioengineers. Design, and optimization of novel devices, as well as improvement of existing cardiovascular devices are major interests of this lab.
Selected Publications:
1. Weinberger, J, Lincoff AM, Popma J.Endovascular radiation, local drug delivery and.embolization protection devices. In: Topol EJ, ed. Comprehensive Cardiovascular Medicine, 2nd ed.
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2. Wuu CS, Schiff P, Marek, Maryanski J, Liu T, Borzillary S, and Weinberger J. (2003) Dosimetry study of Re-188 liquid balloon for intravascular brachytherapy using polymer gel dosimeters and laser-beam optical CT scanner. Medical Physics
30(2):132-7
3. Schwartz RS. Edelman ER. Carter A. Chronos N. Rogers C. Robinson KA. Waksman R. Weinberger J. Wilensky RL. Jensen DN. Zuckerman BD. Virmani R. (2002) Drug-eluting stents in preclinical studies: recommended evaluation from a consensus group. Circulation
106(14):1867-73
4. Qu X, and Weinberger, J. (2000) Novel beta-emitting poly(ethylene terephthalate) surface modification. J Biomed Mater Res
52:492–7
5. Nath R, Yue N, Weinberger J. (1999) Dose perturbations by high atomic number materials in intravascular brachytherapy. Cardiovascular Radiation Medicine
1(2):144-53
6. Weinberger J. (1998) Intracoronary radiation using radioisotope-filled balloons. Herz
23(6):366-72
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