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Research Summary
The research interests of my laboratory and clinical staff are to understand the mechanisms of autoimmune disease, in particular, autoimmune diabetes, and develop novel approaches to treatment of this as well as other autoimmune diseases.
Research Activities
Our studies involve two clinical programs and basic studies that support this work. We are studying the effects of a non-FcR binding anti-CD3 antibody on human Type 1 diabetes. In a Phase I/II trial, we have shown that treatment with this antibody can reduce the rate of loss of insulin secretion in patients with new onset disease. Further clinical studies are in progress to determine whether the effect of the drug can be maintained for a prolonged period and to address whether there is evidence for beta cell regeneration in patients who are treated with the drug after induction of tolerance to autoimmunity. Parallel studies are being carried out in an animal model of Type 1 diabetes to determine whether beta cell regeneration occurs in the remission of diabetes that is induced with anti-CD3 antibody.
Our studies have suggested that treatment with anti-CD3 antibody may induce regulatory cells and/or phenomenon. Our laboratory is focused on identifying cells and/or mediators of inhibition of autoimmunity and understanding how they function.
In addition to inducing tolerance to autoimmunity with anti-CD3 antibody, clinical and basic studies are ongoing to restore lost beta cells with islet transplantation. Our first clinical transplants are being done in patients with pre-existing renal transplants. In addition, we are studying ways of modifying the islet allografts to be transplanted in ways that will prevent recurrent autoimmunity and allorejection. As an example, we are studying the effects of a soluble inhibitor of RAGE (receptor for advanced glycation endproducts) on this process.
Lab website: http://hora.cpmc.columbia.edu/dept/nbdiabetes-old/zzzSiteCopy11-2-2000/about/about/herold.html
Positions & Appointments
| 1998-present |
Associate Attending Physician |
Presbyterian Hospital |
New York, NY |
| 1998-present |
Associate Professor of Clinical Medicine |
Columbia University, College of Physicians & Surgeons |
New York, NY |
| 1998 |
Clinical Associate Professor of Medicine |
Albert Einstein School of Medicine |
Bronx, NY |
| 1998 |
Scientific Director |
Juvenile Diabetes Foundation, Int. |
New York, NY |
| 1996-1998 |
Associate Professor, Department of Medicine, Section of Endocrinology and Metabolism |
University of Illinois at Chicago |
Chicago, IL |
Education and Training
| 1977 |
B.S., Science |
Pennsylvania State University, State College, PA |
| 1979 |
M.D. |
Jefferson Medical College, Philadelphia, PA |
| 1979-1980 |
Intern, Internal Medicine |
Temple University Hospital, Philadelphia, PA |
| 1980-1982 |
Resident in Internal Medicine |
Temple University Hospital, Philadelphia, PA |
| 1982-1984 |
Fellow in Endocrinology |
University of Chicago, Chicago, IL |
| 1984-1986 |
Fellow in Immunology (in Dr. Frank W. Fitch's Laboratory) |
University of Chicago, Chicago, IL |
| 1986-1987 |
Staff Scientist |
Hagedorn Research Laboratory, Gentofte, Denmark |
Honors and Awards
1975 President's Freshman Achievement Award
1977 Graduated Summa Cum Laude
1977 Measey Scholarship
1978 Who's Who Among Students in American Colleges and Universities
1978 Alpha Omega Alpha Honor Medical Society
1979 Graduated Cum Laude
1983, 1985 and 1988 Young Investigators' Research Award, ADA, Northern Illinois Affiliate
1988-1990 Career Development Award, Juvenile Diabetes Foundation International
1990 Clinical Investigator Award, NIDDK, K08 DK01938-01, National Institutes of Health
Committees and Society Memberships
Central Society for Clinical Research
American Diabetes Association
American Federation for Clinical Research
American Association of Immunologists
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