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Research Summary
Effects of exercise and weight loss on the hypothalamic-pituitary gonadal axis and the metabolic signals to the GnRH pulse generator, and on the development of osteopenia in women. Treatment of the menopausal woman. Effects of puberty on behavior.
Research Activities
The following is a list of Dr. Warren’s current research studies:
GnRH Inhibition in Anorexia Nervosa (NIH)
Anorexia Nervosa is associated with severe metabolic disturbances which shut down the reproductive system. This study examines the metabolic signals to reproduction and the return of these signals as patients gain weight. It also examines differences between those who have a return of normal menstrual cyclity and those who do not, including the effect on bone.
Black Cohosh for the Treatment of Menopausal Hot Flashes (NIH)
Black Cohosh has been used for the treatment of menopausal symptoms. This study will examine the effectiveness and safety of the use of the compound as well as the effect on bone density.
Behavior and Physiological Processes in Girls (NIH/NICHD)
This study examines the effect of pubertal development on behavior in girls.
Contextual Behavioral and Physiological Processes in Boys (NIH)
This study examines the effect of pubertal development on behavior in boys.
Women with Exercise Associated Amenorrhea Have a Paradoxical Change in Metabolic Parameters
This study examines the persistence of hypothalamic amenorrhea in individuals of normal weight who exercise heavily.
Lab website: http://www.center-for-menopause.com
Positions & Appointments
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Medical Director, Center for Menopause, Hormonal Disorders, and Women’s Health |
Columbia University Medical Center |
New York, NY |
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Selected Publications:
1. Bronson E, Ramos R, Warren MP. (2002) Exercise-induced Amenorrhea: Are Altered Leptin Levels an Early Warning Sign? The Physician and Sports Medicine
30(10):41-6
2. Warren MP. (2002) Invited editorial: The effects of phytoestrogen supplementation in postmenopausal women. Journal of the Society for Gynecologic Investigation
9(4):184-5
3. Warren MP, Brooks-Gunn J, Fox RP, Holderness CC, Hyle EP, Hamilton WG. (2002) Osteopenia in exercise-associated amenorrhea using ballet dancers as a model: a longitudinal study. Journal of Clinical Endocrinology and Metabolism
87(7):3162-8
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