The investigators studied a group of mice lacking in CREB binding protein, a molecule critical to the formation of long-term memories and deficient in RTS and other memory disorders. They found that the brain circuitry of these mice was significantly altered; they were less able than normal mice to remember having encountered novel objects in their environment and less able to associate specific signals with past negative experiences. Nevertheless, according to the researchers, several drugs-including some already being tested for cancer and Huntington''s disease-can help rebuild the necessary molecular scaffolding and might be useful in restoring some memory capability to patients with Rubinstein-Taybi syndrome.

For more information or to arrange an interview with Dr. Kandel, call Alex Lyda at 212-305-3900 or mal2133@columbia.edu.