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Ramon E. Parsons, M.D., Ph.D.
Avon Foundation Associate Professor of Breast Cancer Research in the Institute for Cancer Genetics and in the Herbert Irving Comprehensive Cancer Center
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Research
Summary
The genetics of breast cancer tumorigenesis.
CURRENT RESEARCH:
We are focusing our efforts on the pathogenesis of breast cancer. Our aim is to identify the genetic and biochemical changes that lead a normal cell to develop into an advanced tumor. The genes targeted by these changes will then be analyzed to determine their normal function. We identified a tumor suppressor gene, PTEN, that is mutated in breast, brain, prostate, and endometrial cancer. Our present goals are to (1) study the normal function of the PTEN gene and (2) understand its relationships with the PI3K pathway and other signaling pathways in normal cells and cancer. Understanding the network of changes that are selected in cancer will hopefully lead to efficacious therapeutic approaches.
http://icg.cpmc.columbia.edu/faculty_Parsons.htm
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Selected Publications:
1. Simpson L., Li J., Liaw D., Hennessy I., Oliner J., Christians F., Parsons R. (2001) PTEN expression causes a feedback upregulation of IRS2. Mol. and Cell.Biology
21:3947-3958
2. Podsypanina K., Lee R.T., Politis C., Crane A., Puc J., Neshat M., Wang H., Yang L., Gibbons J., Frost P., Dreisbach V., Blenis J., Gaciong Z., Fisher P., Sawyers C., Hedrick-Ellenson L., Parsons R. (2001) An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten +/- mice. Proc. Natl. Acad. Sci. (USA)
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3. Puc J, Keniry M, Li HS, Pandita TK, Choudhury AD, Memeo L, Mansukhani M, Murty VVVS, Gaciong Z, Meek SEM, Piwnica-Worms H, Hibshoosh H, and Parsons R. (2005) Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell
7:193-204
4. Saal LH, Holm K, Maurer M, Memeo L, Su T, Wang X, Yu JS, Malmström P, Mansukhani M, Enoksson J, Hibshoosh H, Borg Å, Parsons R. (2005) PIK3CA mutations correlate with hormone receptors, node metastasis, ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Research
65:2554-2559
5. Puc J, Parsons R. (2005) PTEN loss inhibits CHK1 to cause double-stranded DNA breaks in cells. Cell Cycle
4:927-929
6. Krop I, Parker MT, Bloushtain-Qimron N, Porter D, Gelman R, Sasaki H, Maurer M, Terry MB, Parsons R, Polyak K. (2005) HIN-1, an inhibitor of cell growth, invasion and AKT activation. Cancer Research
65:9659-9669
7. Kushner JA, Simpson L,Wartschow LM, Rankin MM, Parsons R, White MF. (2005) PTEN regulation of glucose homeostasis and islet growth. Journal of Biological Chemistry
280:39388-39393
8. Bayascas JR, Leslie NR, Parsons R, Flemming S, and Alessi DR. (2005) Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN+/- mice. Current Biology
15:1839-1846
9. Saal LH, Johansson P, Holm K, Gruvberger-Saal SK, She QB, Bendahl P, Maurer M, Koujak S, Malmström P, Memeo L, Isola J, Rosen N, Hibshoosh H, Ringnér M, Borg Å, Parsons R. (2007) Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc Natl Acad Sci USA
104:7564-7569
10. Saal, L.H., Gruvberger-Saal S.K., Persson, C., Lövgren, K., Jumppanen, M., Staaf, J., Jönsson, G., Pires, M.M., Maurer, M., Holm, K., Koujak, S., Subramaniyam, S., Vallon-Christersson, J., Olsson, H., Su, T., Memeo, L., Ludwig, T., Ethier, S.P., Krogh, M. (2008) Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet.
40(1):102-107
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